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ASTM F750-87(2007)e1

Historical Revision

Standard Practice for Evaluating Material Extracts by Systemic Injection in the Mouse

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1.1 This practice covers a nonspecific, acute toxicity test used for detecting leachables from materials used in medical devices.

1.2 The liquids injected into the mouse are those obtained by Practice F 619 where the extraction vehicles are saline, vegetable oil, or other liquids simulating human body fluids.

1.3 Two procedures are outlined: Method A for intravenous injection and Method B for intraperitoneal injection.

1.4 This practice is one of several developed for the assessment of the biocompatibility of materials. Practice F 748 may provide guidance for the selection of appropriate methods for testing materials for a specific application.


This practice is intended to help assess the biocompatibility of materials used in medical devices. It is an acute toxicological test designed to detect the presence of injurious leachable substances.

This practice may not be appropriate for all types of implant applications. The user is cautioned to consider the appropriateness of the method in view of the materials being tested, their potential applications, and the recommendations contained in Practice F 748.

The only limitation applicable is the extract preparation. Refer to Sections 4.3 and 4.4 of Practice F 619 for a description of this limitation.

SDO ASTM: ASTM International
Document Number F750
Publication Date Feb. 1, 2007
Language en - English
Page Count 3
Revision Level 87(2007)e1
Supercedes
Committee F04.16
Publish Date Document Id Type View
June 1, 2020 F0750-20 Revision
Feb. 1, 2007 F0750-87R07E01 Revision
Oct. 1, 2012 F0750-87R12 Reaffirmation
Feb. 1, 2007 F0750-87R07 Reaffirmation
Sept. 25, 1987 F0750-87R02E01 Reaffirmation
Sept. 25, 1987 F0750-87R02 Reaffirmation
Sept. 25, 1987 F0750-87R96 Reaffirmation