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ASTM F719-81(2012)

Current Reaffirmation

Standard Practice for Testing Materials in Rabbits for Primary Skin Irritation

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1.1 This practice covers a procedure by which the irritancy of a biomaterial may be assessed through contact with abraded and intact skin of rabbits.

1.2 The results of this practice depend upon the effectiveness with which contact between the skin and the test material is established and maintained. Because of the operator technique included in performing this test, it is important that the test be performed by personnel with appropriate training.

1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard.

1.4 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.


4.1 Materials that are to be in contact with the skin should not cause irritation to the skin. Since it is probably the substances leached from a material that cause the irritation, this practice provides for direct material-skin contact testing or for skin exposure to the liquid extract of the test material. The rationale for this rabbit test is that it is a comparatively quick and inexpensive method which, through use over the years, has become a generally accepted method.

SDO ASTM: ASTM International
Document Number F719
Publication Date Oct. 1, 2012
Language en - English
Page Count 3
Revision Level 81(2012)
Supercedes
Committee F04.16
Publish Date Document Id Type View
April 1, 2020 F0719-20E01 Revision
April 1, 2020 F0719-20 Revision
Feb. 1, 2007 F0719-81R07E01 Revision
Oct. 1, 2012 F0719-81R12 Reaffirmation
Feb. 1, 2007 F0719-81R07 Reaffirmation
April 24, 1981 F0719-81R02E01 Reaffirmation
April 24, 1981 F0719-81R02 Reaffirmation
April 24, 1981 F0719-81R96E01 Reaffirmation