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ASTM E1147-92(2005)

Current Revision

Standard Test Method for Partition Coefficient (N-Octanol/Water) Estimation by Liquid Chromatography (Withdrawn 2013)

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1.1 This test method describes a procedure for the estimation of the log of the octanol/water partition coefficient (log Kow) of chemicals over the range from 0 to 8.

1.2 This test method uses an empirically derived equation to relate the octanol/water partition coefficient to an experimentally determined retention time on a liquid chromatographic column.

1.3 This test method has been designed to estimate log Kow values for both non-ionizable and ionizable compounds. This is accomplished by buffering the liquid chromatographic solvent at a pH that will force the test compound into either the non-ionized or ionized form.

1.4 This test method requires some knowledge of the detector response to the chemical being tested.

1.5 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish safety and health practices and determine the applicability of regulatory limitations prior to use.


SDO ASTM: ASTM International
Document Number E1147
Publication Date Aug. 1, 2005
Language en - English
Page Count 4
Revision Level 92(2005)
Supercedes
Committee E47.04
Publish Date Document Id Type View
Aug. 1, 2005 E1147-92R05 Revision
Jan. 1, 1997 E1147-92R97 Reaffirmation