Logo

ASTM D6259-98(2010)

Historical Reaffirmation

Standard Practice for Determination of a Pooled Limit of Quantitation for a Test Method

$73.00

$73.00

$131.40


Sub Total (1 Item(s))

$ 0.00

Estimated Shipping

$ 0.00

Total (Pre-Tax)

$ 0.00


...

1.1 This practice covers the determination of a lower quantitative limit for a test method for an analyte. The determined lower limit is hereinafter referred to as the pooled limit of quantitation.

1.2 Applicable test methods will produce test results greater than zero. Examples are those test methods that measure sample composition.


In a single laboratory, the limit of quantitation, LOQ, equal to ten standard deviations has been recommended.4 A test result at this LOQ has an uncertainty of ±30 % at the 99 % confidence level. Similarly here, as a general estimate, the PLOQ, equal to ten repeatability standard deviations is recommended. A test result at this PLOQ has an uncertainty of ±30 % at the 99 % confidence level.

Values below the PLOQ are deemed to be too uncertain for meaningful use in commerce, or in regulatory activities.

Many test methods never find application outside their PLOQ. However, in the quest for ever more sensitive procedures, it can become difficult to distinguish an analytical response from background noise with the technology at hand. Test methods defective in design or poorly executed may also function outside their PLOQ.

SDO ASTM: ASTM International
Document Number D6259
Publication Date July 1, 2010
Language en - English
Page Count 3
Revision Level 98(2010)
Supercedes
Committee D02.94
Publish Date Document Id Type View
May 1, 2023 D6259-23 Revision
July 1, 2015 D6259-15 Revision
April 10, 1998 D6259-98 Revision
May 1, 2019 D6259-15R19 Reaffirmation
July 1, 2010 D6259-98R10 Reaffirmation
May 1, 2004 D6259-98R04 Reaffirmation